Global and regional brain concentration of intra- and extra- cellular sodium in MS: a 7 Tesla MRI study
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چکیده
Global and regional brain concentration of intraand extracellular sodium in MS: a 7 Tesla MRI study Matilde Inglese, Maria Petracca, Roxana Teodorescu, Laura Jonkman, Niels Oesingmann, and Lazar Fleysher Neurology, Icahn School of Medicine at Mount Sinai, New York, New York, United States, Icahn School of Medicine at Mount Sinai, New York, New York, United States, Siemens Healthcare, New York, New York, United States, Radiology, Icahn School of Medicine at Mount Sinai, New York, New York, United States
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Brain intra- and extracellular sodium concentration in multiple sclerosis: a 7 T MRI study.
Intra-axonal accumulation of sodium ions is one of the key mechanisms of delayed neuro-axonal degeneration that contributes to disability accrual in multiple sclerosis. In vivo sodium magnetic resonance imaging studies have demonstrated an increase of brain total sodium concentration in patients with multiple sclerosis, especially in patients with greater disability. However, total sodium conce...
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